Methylphenidat

Zusammenfassung

Ein Psychostimulans, das häufig zur Behandlung von ADHS, Narkolepsie und Fettleibigkeit eingesetzt wird, insbesondere in der EU anstelle von Adderall. Methylphenidat ist auch ein Agonist des 5HT1A-Rezeptors. Manchmal wird es off-label verschrieben, um bei Entzugserscheinungen von Kokain und anderen Stimulanzien zu helfen.

Dosierung

Nasal

Oral

Wirkungsverlauf

• Nachwirkungen: 1-24 Stunden

Wirkungen

• Erhöhte Wachsamkeit
• Euphorie
• Erhöhte Motivation
• Verminderter Appetit
• Gesichtsrötung
• Erhöhte Körpertemperatur
• Tachykardie (Erhöhter Herzschlag) Paranoia
• Schlaflosigkeit

Subjektive Wirkungen (PsychonautWiki)

• Analysis enhancement
• Anxiety
• Appetite suppression
• Cognitive euphoria
• Cognitive fatigue
• Dehydration
• Depression
• Focus enhancement
• Increased heart rate
• Increased perspiration
• Irritability
• Memory enhancement
• Motivation enhancement
• Stimulation
• Teeth grinding
• Thought acceleration
• Thought deceleration
• Thought organization
• Wakefulness

Quellen

• A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid - http://www.ncbi.nlm.nih.gov/pubmed/526558
• Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans. - http://www.ncbi.nlm.nih.gov/pubmed/8109495
• Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol. - https://www.ncbi.nlm.nih.gov/pubmed/10820132
• A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during... - https://www.ncbi.nlm.nih.gov/pubmed/22289608
• Methylphenidate and brain dopamine neurotoxicity. - http://www.ncbi.nlm.nih.gov/pubmed/9365033
• Methylphenidate treatment induces oxidative stress in young rat brain. - http://www.ncbi.nlm.nih.gov/pubmed/16494852
• A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. - http://www.ncbi.nlm.nih.gov/pubmed/17201613
• Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity. - http://www.ncbi.nlm.nih.gov/pubmed/17218796
• The psychostimulant d-threo-(R,R)-methylphenidate binds as an agonist to the 5HT(1A) receptor. - http://www.ncbi.nlm.nih.gov/pubmed/19322953
• Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder - http://www.ncbi.nlm.nih.gov/pubmed/19877980
• Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction - http://www.ncbi.nlm.nih.gov/pubmed/24261661
• Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate. - http://www.ncbi.nlm.nih.gov/pubmed/24631430
• Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats. - http://www.ncbi.nlm.nih.gov/pubmed/26509840
• A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid. - http://www.ncbi.nlm.nih.gov/pubmed/526558
• A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the w... - https://www.ncbi.nlm.nih.gov/pubmed/22289608
• Methylphenidate and brain dopamine neurotoxicity. - https://www.ncbi.nlm.nih.gov/pubmed/9365033
• Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a random... - http://www.ncbi.nlm.nih.gov/pubmed/19877980
• Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta... - http://www.ncbi.nlm.nih.gov/pubmed/26509840
• IV use of methylphenidate can lead to infections and abscesses due to the fillers in the medication - http://onlinelibrary.wiley.com/doi/10.1002/hed.2890060409/full
• Pregnancy category C according to the FDA - http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/010187s069,018029s040,021284s011lbl.pdf